John Witte, Ph.D. University of California, San Francisco (UCSF).

John Witte is Professor of Epidemiology and Biostatistics at the University of California, San Francisco where he also serves as the Associate Director of the Institute for Human Genetics. Dr. Witte received his PhD in Epidemiology from UCLA and had his first faculty appointment in the Department of Preventive Medicine at the University of Southern California. Prior to joining UCSF, he spent eight years at Case Western Reserve University, in the Division of Genetic and Molecular Epidemiology.

Dr. Witte’s research constitutes applied and methodologic genetic epidemiology, with the overall aim of deciphering the mechanisms underlying complex diseases. He has initiated a series of prostate cancer genetic epidemiology studies, which have had numerous successes toward sorting out the genetic basis of this disease. These include findings from searches across the human genome and from work on specific candidate genes. In particular, using a combination of genome-wide scan, allelic imbalance, and association studies, Dr. Witte and colleagues have isolated distinct chromosomal regions that appear to harbor genes that cause prostate cancer.

Dr. Witte’s methodological research mostly involves issues surrounding the design and analysis of genetic epidemiologic studies. Dr. Witte has provided extensive applications of hierarchical modeling, including for investigating genetic pathways and gene-environment interactions. His work has led to the growing use of hierarchical modeling, and the development of additional tools for such analyses.

Dr. Witte is a Collaborator on this study.

For more information about the University of California, San Francisco (UCSF):
http://www.ucsf.edu

For more information about the Institute for Human Genetics at UCSF:
http://humgen.medschool.ucsf.edu

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