Most SNPs in genes identified thus far have no functional consequence, as they do not alter the structure of proteins coded by that gene. In trying to associate SNPs with health-related outcomes, it is more effective to focus on that subset of SNPs that do cause a change in the protein--this type of variation is called functional variation.
At VitaPath we focus our research primarily on SNPs that cause functional changes as they represent the most clinically relevant forms of genetic variation. In order to assess the functional consequences of SNP variations, our Technology Platform uses a yeast model systems to obtain a direct, biochemical measurement of a particular SNPs influence.
Once functional SNPs have been identified and characterized, we use this very selective set to associate genetic variation with health and disease.
To read more about our functional SNP approach: http://www.pnas.org/content/105/23/8055.full.pdf
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